This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Genome-wide association studies (GWASs) have provided evidence for a polygenic architecture of most common disorders.1 By accumulating power with increasing sample sizes and increasing representation across ancestries, GWASs have detected thousands of loci across the genome associated with complex vascular diseases including stroke.2 Polygenic risk scores (PRSs) aggregate this information at an individual level by adding the number of genetic risk variants a person carries, weighted by the effect sizes from GWASs. Since their first description, PRSs were considered a means toward the clinical implementation of GWAS-derived data by consolidating complicated genomic data into a simple numerical biomarker representing an individual's genetic risk for a disease.3 Similar to other complex traits, PRSs for ischemic stroke and intracerebral hemorrhage are strongly associated with risk of incident events in population-based settings and independently of clinical risk factors, such as hypertension.2,4 However, despite innovations in PRS construction and improvements in their predictive ability, there has been to date no strong evidentiary support for their use in clinical and public health practice.5
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.
See page 706
- Received December 6, 2022.
- Accepted in final form December 21, 2022.
- © 2023 American Academy of Neurology
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
