@article {Sawadogo10.1212 / WNL。0000000000207449,作者= {Wendemi Sawadogo和Tilahun Adera和马汉Alattar和罗伯特·B·佩雷拉和詹姆斯·伯奇},title ={失眠症状之间的联系和轨迹与中风的危险健康和退休研究},elocation-id = {10.1212 / WNL。={2023}0000000000207449},年,doi = {10.1212 / WNL。出版商0000000000207449}= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景和目标:失眠是一种常见的条件影响超过三分之一的美国人口。半岛投注体育官网然而,失眠症状之间的联系和中风是可以理解和底层的机制尚不清楚。本研究旨在探讨失眠症状和中风的发病率之间的关系。方法:健康和退休研究,调查美国人年龄超过50年和他们的配偶,从2002年到2020年被用作数据源。只有那些在基线stroke-free被纳入本研究。暴露变量失眠症状,源自自我报告的睡眠相关因素包括入睡困难,难以维持正常睡眠,醒来太早,。睡后精力未恢复重复测量潜类别分析用来确定失眠轨迹。探讨失眠症状之间的关系和中风事件报道在随访期间,cox比例风险回归模型。 Mediation analyses of comorbidities were performed utilizing causal mediation within a counterfactual framework.Results: A total of 31,126 participants were included with a mean follow-up of 9 years. The mean age was 61 years (SD=11.1) and 57\% were female. Insomnia symptom trajectories remained constant over time. Compared to subjects with no insomnia symptoms, an increased risk of stroke was observed for those with insomnia symptom scores ranging from 1 to 4 and 5 to 8 (hazard ratio (HR) = 1.16, 95\% confidence interval (CI): 1.02, 1.33) and (HR =1.51, 95\% CI: 1.29, 1.77), respectively indicating a dose-response relationship. The association was stronger in participants aged less than 50 years (HR=3.84, 95\% CI: 1.50, 9.85) than those 50 years and above (HR=1.38, 95\% CI: 1.18, 1.62) comparing those with insomnia symptoms ranging from 5 to 8 to those with no insomnia symptoms. This association was mediated by diabetes, hypertension, heart disease, and depression.Discussion: Insomnia symptoms were associated with an increased risk of stroke, especially in adults younger than 50 years, and the risk was mediated by certain comorbidities. Increased awareness and management of insomnia symptoms may contribute to the prevention of stroke occurrence.Key terms:}, issn = {0028-3878}, URL = {//www.ebmtp.com/content/early/2023/06/07/WNL.0000000000207449}, eprint = {//www.ebmtp.com/content/early/2023/06/07/WNL.0000000000207449.full.pdf}, journal = {Neurology} }