肿胀的外层视网膜层在急性视神经炎(P4.042)

文摘

背景:先前的研究已经表明视网膜神经纤维层(RNFL)肿胀急性视神经炎(AON)。在这个队列的患者,在2周的视力丧失,我们确认和扩展这些调查结果,显示早期小说外层视网膜层的变化。目的:考察怡安的影响在黄斑视网膜层和papillo-macular包(PMB)。方法:46怡安例(33人,13名女性,平均年龄35)被招募在14天的视力丧失。视神经盘旁RNFL厚度、黄斑体积和PMB扫描。视网膜细分进行了分析。平均RNFL厚度措施,神经节细胞和内网状层(GC / IPL),内部核+外网状层(在/ OPL)。除了复合神经节细胞的复杂(GCC = GC / IPL + NFL),外层视网膜复杂(兽人=外核层+感光层)和总视网膜厚度。结果:总黄斑视网膜厚度明显更大的影响比其他眼(p = 0.008)。兽人黄斑厚度也显著更大的平均影响眼(p = 0.001) 2例可见液体在这一层。 ORC thickness in both the nasal and temporal macular was increased uniformly when compared to the fellow eye. Total PMB thickness was significantly greater in the affected compared to the fellow eye(p=0.093). Average PMB GCC and ORC layers were significantly thicker in the affected eye(p=0.043, p=0.033 respectively). Peripapillary RNFL swelling was not significantly correlated with ORC thickness in the macula or PMB but was correlated with PMB GCC thickness(p= 0.0003). Conclusions: We found significant swelling in the ORC(macula & PMB) and GCC layers(PMB). Swelling of the ORC has not been reported previously in acute optic neuritis. The uniform nasal and temporal swelling and lack of correlation with RNFL thickness suggests a mechanism for ORC swelling other than spread of oedema from an inflamed optic nerve. A possible mechanism would be intrinsic cytotoxic oedema.

披露:Raftopoulos博士没有披露。陈竺没有披露。西克曼博士没有披露。Toosy博士没有披露。Wheeler-Kingshott博士已经收到个人活动与生原体补偿Idec作为一个顾问委员会成员。•阿尔特曼博士已经收到个人活动与默克公司补偿公司Mallik博士没有披露。木栅博士没有披露。Yiannakas博士没有披露。博士主要受到个人补偿活动与赛诺菲-安万特制药公司诺华,默克公司Serono议长。谢里丹博士没有披露。 Dr. Sharrack has nothing to disclose. Dr. Giovannoni has received personal compensation for activities with AbbVie, Biogen Idec, Canbex Therapeutics, Genzyme Sanofi, Ironwood Pharmaceuticals Inc., Novartis, Merck, Merck Serono, Roche, Synthon, Teva, Vertex, and Bayer Schering Pharma as a scie Dr Balcer received personal compensation from Biogen Idec and consulting for Biogen Idec, Vaccinex and Genzyme. She is on a clinical trial advisory board for Biogen-Idec., Prof. Miller has received honoraria through payments to his employer, UCL Institute of Neurology, for Advisory Committee and/or Consultancy advice in multiple sclerosis studies from Biogen Idec,;, Dr. Ishikawa has nothing to disclose. Dr. Kapoor received personal compensation for activities with Biogen Idec, Novartis, Genzyme, and Teva.