文摘
摘要目的:描述在新加坡与COVID-19相关的神经系统疾病。
背景:各种神经系统疾病在COVID-19已报告的病人。假设机制包括hypercoagulopathy、免疫异常、炎症和直接病毒入侵。SARS-CoV-2发病率和关系,考虑COVID-19激增的混杂效应情况下在医疗保健系统中,尚不清楚。
设计/方法:全国,这是一个潜在的多中心队列研究的患者microbiologically-confirmed COVID-19提到任何神经系统感染的投诉3个月内。神经诊断和关系COVID-19是由共识的指导下发表情况下定义。
结果:March-July 2020年之间,47572名患者(平均年龄34(1 - 102)年,98%的男性)被诊断出患有COVID-19在新加坡。90病人神经紊乱,39岁(平均年龄41(27 - 73)年,97%的男性)被认为与COVID-19和归类为:i)中枢神经系统症状- 3脑炎、1急性播散性脑脊髓炎;(二)脑血管疾病- 19急性缺血性卒中/短暂性脑缺血发作(AIS / TIA), 4脑静脉血栓形成(CVT)和颅内出血2;3)周围神经系统- 7单/多神经病;(四)自主神经系统- 4有限的神经异常。51个其他患者前/ co-existent神经疾病(头痛、癫痫、单一神经病变和功能神经紊乱)与COVID-19无关。脑炎是推迟,发生在临界COVID-19, CVT和神经异常相对较早,主要发生在轻微的感染。AIS / TIA发病变量;有63.2%无症状COVID-19。CVT比预期的更频繁,发生在患者轻度/无症状COVID-19。 The pathophysiology of COVID-19 neurology appeared to be dysimmunity and/or prothrombotic tendency. There were no neurological complications in all 81 paediatric COVID-19 cases.
结论:COVID-19神半岛投注体育官网经学有一个广泛的dysimmune-thrombotic紊乱。记录的相对较少的情况下,可能是因为我们的爆发主要影响健康的年轻男性轻度/无症状COVID-19和大流行性流感没有过度影响新加坡医疗保健系统。
披露:锄头博士没有披露。茉莉花茶Koh,黑带大师没有披露。Deidre De Silva没有披露。艾米林郭先生没有披露。卫生博士没有披露。涂博士没有披露。表面没有披露博士。赛博士没有披露。许博士没有披露。Jasmyn德莱昂没有披露。 Justin Ker has nothing to disclose. Dr. Yong has nothing to disclose. Dr. Goh has nothing to disclose. Wai-Yung Yu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Philips Electronics Singapore PTE LTD. Wai-Yung Yu has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Stryker Singapore PTE LTD. Tchoyoson Lim has nothing to disclose. Benjamin Yong Qiang Tan, 8130 has nothing to disclose. Dr. Ng has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Pfizer. The institution of Dr. Yeo has received personal compensation in the range of $0-$499 for serving as a Consultant for J&J. The institution of Dr. Yeo has received personal compensation in the range of $0-$499 for serving as a Consultant for stryker. Dr. Yeo has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for NUHS. Dr. Yeo has received stock or an ownership interest from cereflo. The institution of Dr. Yeo has received research support from NMRC. Yu Zhi Pang has nothing to disclose. Prakash Kumar, MD has nothing to disclose. Dr. Ahmad has nothing to disclose. Terrence Thomas has nothing to disclose. David Lye has nothing to disclose. Dr. Tan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai. Dr. Tan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Viela Bio. Dr. Tan has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Umapathi Thirunagnam has nothing to disclose.
