文摘
摘要目的:评估与恢复相关的因素从2019年冠状病毒病(COVID-19)在多发性硬化症患者(pwm)
背景:重要的是要理解的恢复过程COVID-19 pwm中找出那些最容易受到感染的长期后遗症。
设计/方法:英国注册COVID-19女士是一个以社区为基础的前瞻性群组研究pwm推出了3月17日,2020年。我们一直在收集数据从参与者(n = 6618年10月5日,2020年)每两周时间的报名学习。我们要求参与者关于COVID-19和跟随他们通过他们的复苏。英国女士登记持有pre-COVID-19纵向和前瞻性收集patient-reported数据包括网络扩大残疾状态量表(webEDSS),影响规模(MSIS-29)女士和医院焦虑和抑郁量表(已经)分数。
结果:709名参与者的自我诊断COVID-19 391对后续的调查问卷。76% (n = 297)已经完全恢复,15.9% (n = 62)主要是恢复和8.2% (n = 32)仍出现症状的时候他们最新的后续。全面复苏的实验对象中,中值(差)疾病的持续时间是10天(6 - 21)。参与者没有恢复完全已经进行了中位数(差)的持续时间105(35 - 131)天。pwm较高webEDSS得分(-0.93或0.78,95% ci 0.65)或物理组成部分MSIS-29得分(-0.98或0.97,95% ci 0.96)的人则较少报告完全康复。存在的焦虑(HADS-anxiety≥11),记录前一年大流行,完全恢复的概率较低有关(或0.26,95%可信区间0.10 - -0.66)。人口统计、疾病修饰治疗持续时间、女士或相关类型的女士没有复苏。
结论:身体残疾和焦虑之前流行的主要决定因素是持续COVID-19症状在患者MS。
披露:Garjani博士已经收到女士的社会研究支持。尼古拉斯博士已经收到个人薪酬在500 - 4999美元的范围为诺华公司担任顾问。尼古拉斯博士已经收到个人薪酬在500 - 4999美元的范围作为顾问生原体。尼古拉斯博士已经收到个人补偿的范围0 - 499美元为在科学咨询服务或数据安全监测委员会罗氏。米德尔顿先生没有披露。凯瑟琳Tuite-Dalton没有披露。蕾切尔猎人没有披露。罗山Das Nair已收到个人薪酬在500 - 4999美元的范围在生原体的演讲人。制度的罗山Das Nair收到女士的社会研究支持。罗山Das Nair的机构已经接到NIHR研究支持。 The institution of Roshan Das Nair has received research support from MRC. The institution of Roshan Das Nair has received research support from Stroke Association. Roshan Das Nair has received publishing royalties from a publication relating to health care. Roshan Das Nair has received personal compensation in the range of $5,000-$9,999 for serving as a Chair of RfPB RAC East Midlands with NIHR. Dr. Evangelou has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Evangelou has received personal compensation in the range of $500-$4,999 for serving as a Consultant for biogen. Dr. Evangelou has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for biogen. Dr. Evangelou has received personal compensation in the range of $500-$4,999 for serving as an Expert Witness for UK crown prosecution service.
