脑代谢与轻度认知障碍和Phenoconversion隔离患者REM睡眠行为障碍

Survival Curves of Phenoconversion to Parkinson Disease or Dementia With Lewy Bodies (A) Mild cognitive impairment (MCI)–normal cognition (NC) was not associated with phenoconversion to Parkinson disease (PD)/dementia with Lewy bodies (DLB). (B) Mean FDG uptake within the clusters showing significant hypometabolism in the isolated REM sleep behavior disorder (iRBD)–MCI group compared with the iRBD–NC group was extracted from each participant. The clusters were divided into anatomical structures using the Harvard-Oxford atlas. (C) Baseline glucose metabolism in the occipital pole, medial occipital, and precuneus predicted phenoconversion to PD/DLB after adjusting for age and duration of iRBD. The cutpoint was defined as the 1 SD value of the mean ¹⁸F-fluorodeoxyglucose (FDG) uptake in HC. HR = hazard ratio.